The 10 Biggest U.S. Startup Funding Rounds This Week: AI, Energy, and Biotech Dominate

U.S. startups closed a wave of major funding rounds during a shortened holiday week, led by a $1.75B strategic investment in energy infrastructure firm Joulent. AI infrastructure, compliance tech, and biotech also featured prominently across the top 10 deals.

U.S. startups maintained a strong funding pace during a truncated holiday week, with energy infrastructure, AI, and biotech accounting for the bulk of capital raised. The week's deals ranged from a multi-billion-dollar energy play to a landmark raise in professional lacrosse.

The Top 10 Rounds at a Glance

1. Joulent — $1.75B | Energy Infrastructure

Houston-based Joulent secured the week's largest round: a $1.75 billion strategic financing backed by National Grid through its National Grid Ventures arm. The company builds energy infrastructure tailored to the demands of AI and other compute-intensive industries.

2. Together AI — $800M | AI Infrastructure

Together AI, which provides an infrastructure layer for companies running open source AI models, raised $800 million in a Series C round led by Aramco Ventures. The deal values the San Francisco-based startup at $8.3 billion post-money.

3. LeapXpert — $180M | Compliance Tech

New York-based LeapXpert, whose tools help enterprises track communications for regulatory compliance, closed $180 million in growth financing led by Riverwood Capital.

4. 8090 Solutions — $135M | AI Software Development

Redwood City-based 8090 Solutions raised $135 million in a round led by Salesforce Ventures for its platform that uses coordinated AI agents under human oversight to build enterprise software. The company was founded in 2024 and counts Chamath Palihapitiya as co-founder and CEO.

5. Beeline Medicines — $126M | Biotech

Boston-based Beeline Medicines extended its Series A by $126 million, backed by Bain Capital, CPP Investments, and Bristol-Myers Squibb. The biotech focuses on precision therapies for autoimmune and inflammatory diseases, and has now raised a total of $426 million at the Series A stage.

6 (tied). Premier Lacrosse League — $100M | Professional Sports

The Premier Lacrosse League closed a $100 million Series E led by Ares Management and Joe Tsai — described as the largest capital raise in professional lacrosse history.

6 (tied). Twelve Labs — $100M | Video AI

San Francisco-based Twelve Labs, which builds AI systems trained on video archives, raised $100 million in a Series B co-led by New Enterprise Associates and Naver Ventures.

8. Higharc — $95M | AI for Homebuilding

Durham, North Carolina-based Higharc picked up $95 million in Series C funding led by Insight Partners. The company develops AI-powered tools for home design and homebuilding workflow management.

9. Flare Therapeutics — $85M | Biotech

Cambridge, Massachusetts-based Flare Therapeutics raised $85 million in a Series C led by Third Rock Ventures and Nextech Invest. The startup targets transcription factors to develop treatments for cancer and other diseases.

10. Venice — $65M | AI Privacy

Venice, a Sheridan, Wyoming-based platform offering private, surveillance-free access to a range of AI models, secured $65 million in a Series A led by Dragonfly. The round values the 2-year-old startup at $1 billion.

Key Themes This Week

Energy for AI is becoming a standalone investment category, with Joulent's raise signaling major capital flowing into compute-adjacent infrastructure.
Open source AI infrastructure continues to attract outsized rounds — Together AI's $800M Series C reflects sustained investor conviction in the layer beneath frontier models.
Biotech delivered two notable rounds across different therapeutic focuses, reinforcing the sector's resilience.
Across the board, Series A through Series C stages dominated, suggesting investors are still deploying aggressively into growth-stage companies.

Rounds tracked cover U.S.-based companies for the period of June 27–July 2, sourced from the Crunchbase database.